Dr. Alain Bopda Waffo
Dr. Alain Bopda Waffo
Associate Professor of Biology
Dept. of Biological Sciences
Dr. Bopda Waffo received both BS and MS degrees from the University of Yaoundé in Cameroon. Dr. Bopda obtained his PhD from Max-Planck-Institute for Biophysical Chemistry of Gottingen in Germany. Dr. Bopda was a post-doctoral researcher in the Universities of Medicine and Dentistry of New Jersey and in the University of Texas in Houston and Galveston. Dr. Waffo was also a research associate in the Department of Microbiology at the University of Alabama at Birmingham, Birmingham Alabama.
Dr. Waffo’s research focuses are as follows: a) RNA-coliphage display as drug cargo and b) immunization with recombinant antigenic polypeptides or proteins coupled to nano-particles. Phage display is a molecular diversity technology that allows gene modification of phage and presentation of biomolecules on its surface. Qphage was shown to be a powerful tool for functional molecules exposition and optimization (Bopda, 2004). More recently Dr. Waffo investigated cellular proteins interacting with the viral proteins during viral infection. Dr. Waffo developed expertise in protein purification and RNA phage display technology. He will be using his expertise and nanotechnology to explore viral shell as well as recombinant antigenic polypeptide for the attachment of drug cargo.
Some of the most recent research publications:
Basu A., A. Bopda-Waffo, V. Thakur, S. Knapp and N. Kaushik-Basu (2010). Functional Characterization of the Full SARS-Co Virus RNA-Dependent RNA-Polymerase (Under revision).
Bopda-Waffo A., Ulrich Kortz, Stefan G. Sarafianos, A. Basu and N. Kaushik-Basu (2010) Polyoxometalates: A Novel Class of HCV NS5B Polymerase Inhibitors (Under revision)
Bopda-Waffo, Alain; Chen, Ye; Basu, Amartya; Krishnan, Ramalingam; Silberstein, Erica; Taylor, Deborah; Talele, Tanaji; Arora, Payal; Kaushik-Basu, Neerja (2009). Aurintricarboxylic Acid: A Highly Potent Hepatitis C Virus Replicase Inhibitor. Antiviral Chemistry & Chemotherapy 20: in press (doi:10.3851/IMP).
Kaushik-Basu N., Bopda-Waffo A., Basu A., Chen Y., Talele TT, and Küçükgüzel SG.4-Thiazolidinones: A Novel Class as Hepatitis C Virus NS5B Polymerase Inhibitors (2008). Frontiers in Bioscience 1;13 : 3857-68.
Kaushik-Basu N., Bopda-Waffo A., A. Basu, Francois Noel, Paulo R. R Costa, and Alcides J. M.(2008) Identification and Characterization of Coumestans as novel HCV NS5B polymerase inhibitors (Nucleic Acid Research doi:10.1093/nar/gkm1178), 1 -15.