Vida Dennis

vida dennis

VIDA A. DENNIS, Ph.D.

Professor of Microbiology
Associate Director CNBR

Center for NanoBiotechnology Research
Alabama State University
1627 Hall Street, Room 307
Montgomery, AL 36101

Phone- (334)-229-8447
Email: vdennis@alasu.edu 

 

 

 

 

 

 

 

 

 

 

Education

     

University of Georgia

 

Ph.D.

      1984      

    Parasitology

Louisiana State University         

     Post-Doc    

  1988 

    Parasitology/Immunology

Professional Appointments

 

2011-present 

Adjunct Professor
University of Alabama at Birmingham (UAB) , Birmingham, AL

2010-present

Associate Director
Center for NanoBiotechnology & Life Sci. Research
 Alabama State University, Montgomery, AL

2014-present

Professor of Microbiology
Alabama State University, Montgomery, AL

2002-2009

Co-Manager of DNA Microarray and Expression Core at TNPRC, Covington, LA

1994-2009

Research Scientist,
Department of Bacteriology and Parasitology
TNPRC, Tulane University, Covington, LA

2007-2009

Adjunct Associate Professor
Tulane School of Public Health and Tropical Medicine,
Tulane University, New Orleans, LA

1988-1994

Associate Scientist,
Department of Bacteriology and parasitology
TNPRC, Tulane Univeristy, Covington, LA

 

Publications (Last 5 years)

1.Glial cell-elicited activation of brain microvasculature in response to Brucella abortus Infection requires ASC inflammasome-dependent IL-1β production. 2016. M. Cruz Miraglia, Miriam M. Costa Franco, Ana. M. Rodriguez, Paula M. Q. Bellozi, Carina C. Ferrari, Maria I. Farias, Vida A. Dennis, Paula Barrionuevo,  Antonio C. P. de Oliveira, Fernando Pitossi, Kwang Sik Kim, M. Victoria Delpino, Sergio Costa Oliveira, and Guillermo H. Giambartolomei. Journal of Immunology (in press)

2. Ejovwoke Dosunmu, Atul A Chaudhari, Shree R Singh, Vida A Dennis, Shreekumar R Pillai. 2015. Silver-coated carbon nanotubes downregulate the expression of Pseudomonas aeruginosa virulence genes: a potential mechanism for their antimicrobial effect. International Journal of Nanomedicine 2015:10 5025–5034.

3. Pooja M Tiwari; Erdal Eroglu; Swapnil S Bawage; Komal Vig; Michael  E Miller; Shreekumar Pilla; Vida A Dennis; Shree R. Singh. 2014. Enhanced intracellular translocation and biodistribution of gold nanoparticles functionalized with a cell-penetrating peptide (VG-21) from vesicular stomatitis virus. Biomaterials 2014 Nov;35(35):9484-94. doi: 10.1016/j.biomaterials.

4. Bibbs RK, Harris RD, Peoples VA, Barnett C, Singh SR, Dennis VA, Coats MT. 2014. Silver polyvinyl pyrrolidone nanoparticles exhibit a capsular polysaccharide influenced   bactericidal effect against Streptococcus pneumoniae. Frontiers Microbiology. 2014 Dec 3;5:665. doi: 10.3389/fmicb.2014.00665.

5. Dixit S, Singh SR, Yilma AN, Agee RD 2nd, Taha M, Dennis VA. 2014. Poly (lactic acid)-poly (ethylene glycol) nanoparticles provide sustained delivery of a Chlamydia trachomatis recombinant MOMP peptide and potentiate systemic adaptive immune responses in mice. Nanomedicine 2014 Mar 3. pii: S1549-9634(14)00044-6. doi: 10.1016/j.nano.2014.02.009.

6. Eroglu E, Tiwari PM, Waffo AB, Miller ME, Vig K, Dennis VA, Singh SR. 2013. A nonviral pHEMA+chitosan nanosphere-mediated high-efficiency gene delivery system. International Journal of Nanomedicine. 2013;8:1403-15. doi: 10.2147/IJN.S43168.

7. Swapnil Bawage, Pooja Tiwari, Shreekumar R. Pillai, Vida A. Dennis and Shree R. Singh. 2013. Recent Advances in Diagnosis, Prevention and Treatment of Human Respiratory Syncytial Virus. 2013. Adv. Virol. Article ID 595768, 26 pages, 2013. doi:10.1155/2013/595768.

8. P.M. Tiwari, E. Eroglu, S. Boyoglu-Barnum, Q. He, G.A. Willing, K. Vig, V.A. Dennis, S.R. Singh. 2013. Atomic force microscopic investigation of respiratory syncytial virus infection in HEp-2 cells. J. Microscopy. doi:10.1111/jmi.12095

9. Cemil Boyoglu, Qingwen He, Gerold Willing, Seyhan Boyoglu-Barnum, Vida A. Dennis, Shreekumar R. Pillai and Shree R. Singh. 2013. Microscopic studies of various sizes of gold nanoparticles and their cellular localization. ISRN Nanotechnology, Volume 2013 (2013), Article ID 123838, 13 pages, http://dx.doi.org/10.1155/2013/123838

10. Abebayehu N. Yilma, Shree R. Singh, Saurabh Dixit, Vida A. Dennis. 2013. Anti-inflammatory effects of silver-polyvinyl pyrrolidone (Ag-PVP) nanoparticles in mouse macrophages infected with Live Chlamydia trachomatis. International journal of Nanomedicine 2013; 8:2421-32. doi: 10.2147/IJN.S44090.

11. Stacie J. Fairley, Shree R. Singh, Abebayehu N. Yilma, Alain B. Waffo, Praseetha Subbarayan, Saurabh Dixit, Murtada A. Taha M, Chino D. Cambridge, Vida A. Dennis. 2013. Chlamydia trachomatis recombinant MOMP encapsulated in PLGA nanoparticles triggers primarily T helper 1 cellular and antibody immune responses in mice: a desirable nanovaccine candidate. International journal of Nanomedicine 2013:8 Pages 2085 – 2099 DOI: http://dx.doi.org/10.2147/IJN.S44155.

12. Abebayehu N. Yilma, Shree R. Singh, Saurabh Dixit, Vida A. Dennis. 2013. Anti-inflammatory effects of silver-polyvinyl pyrrolidone (Ag-PVP) nanoparticles in mouse macrophages infected with Live Chlamydia trachomatis. International journal of Nanomedicine 2013; 8:2421-32. doi: 10.2147/IJN.S44090.

13. Chino D. Cambridge, Shree R. Singh, Alain B. Waffo, Stacie J. Fairley, Vida A. Dennis. 2013. Formulation, characterization and expression of a recombinant MOMP Chlamydia trachomatis DNA vaccine encapsulated in chitosan nanoparticles. International journal of Nanomedicine Volume 2013:8 Pages 1759 – 1771. DOI: http://dx.doi.org/10.2147/IJN.S42723.

14. Eroglu E, Tiwari PM, Waffo AB, Miller ME, Vig K, Dennis VA, Singh SR. 2013. A nonviral pHEMA+chitosan nanosphere-mediated high-efficiency gene delivery system. International Journal of Nanomedicine. 2013;8:1403-15. doi: 10.2147/IJN.S43168.

15. Abebayehu N. Yilma, Shree R. Singh, Lisa Morici  and Vida A. Dennis. “Flavonoid Naringenin: A Potential Immunomodulator for Chlamydia trachomatis Inflammation,” Mediators of Inflammation. International Journal of Nanomedicine  vol. 2013, Article ID 102457, 13 pages, 2013. doi:10.1155/2013/102457 

16. Seyhan  Boyoglu-Barnum, Praseetha Subbarayan, Komal Vig, Shreekumar Pillai, Vida A. Dennis, Shree R. Singh. 2012. Nano-encapsulated DNA and/or protein boost immunizations increase efficiency of DNA vaccine protection against RSV. J. Nanomed. Nanotechnol. Volume 3, Issue 2  1000132

17. Abebayehu N. Yilma, Shree R. Singh, Stacie J. Fairley, Murtada A. Taha, and Vida A. Dennis. 2012. The Anti-Inflammatory Cytokine, Interleukin-10, Inhibits Inflammatory Mediators in Human   Epithelial Cells and Mouse Macrophages Exposed to Live and UV-Inactivated Chlamydia trachomatis. Mediators of Inflammation  Volume 2012 (2012), Article ID 520174, 10 pages

18. Dennis VA, Gautam A, Dixit S. 2012. Modulation of cytokine signaling by B. burgdorferi. In Monica E. Embers, “The Pathogenic Spirochetes strategies for evasion of host immunity and persistence. New York, NY, Springer Science + Business Media. Pages 125-141

19. Aarti Gautam, Saurabh Dixit, Monica Embers, Rajeev Gautam, Mario T. Philipp1, Shree R. Singh, Lisa Morici,  and Vida A. Dennis. 2012. Different Patterns of Expression and of IL-10 Modulation of Pro-Inflammatory Mediators from Macrophages of Lyme Disease-Resistant and Disease-Susceptible Mice. PLoS ONE. 7(9): e43860.

20. Murtada A. Taha, Shree R. Singh, Vida A. Dennis. Biodegradable PLGA85/15 nanoparticles as a delivery vehicle for Chlamydia trachomatis recombinant MOMP-187 peptide. 2012. Nanotechnology 23 (32) 325101 doi:10.1088/0957-4484/23/32/325101.

21. Murtada A. Taha, Kara Hulett, Ronald Agee, Shreekumar R. Pillai,  Shree R. Singh, Vida A. Dennis. 2011. A peptide containing T-cell epitopes of the major outer membrane protein of Chlamydia trachomatis without adjuvant induces systemic and mucosal antibody responses. World Journal of Vaccine 1 (4):138-147.

22. Gautam A, Dixit S, Philipp MT, Singh SR, Morici LA, Kaushal D, Dennis VA. 2011. Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation. Infect Immun. 79(12):4876-92.

Peer-reviewed proceedings (Last 5 years)

1. S.S. Bawage, P.M. Tiwari, V.A. Dennis, S.R. Singh. 2015. Peptide RF482. 2015.  Encapsulated Chitosan – PLGA Nanoparticles Inhibit Respiratory Syncytial Virus. TechConnect World Conference (NSTI), June 14-17, 2015, Washington DC.

2. Saurabh Dixit, Marcus D. Davis, Shree R. Singh and Vida A. Dennis. 2015. Influence of Polyvinyl Alcohol (PVA) on Morphology and Encapsulation Efficiency of Polylactic Acid-Polyethylene Glycol (PLA-PEG) copolymer based Nanoparticle’s. TechConnect World Conference (NSTI), June 14-17, 2015, Washington DC.

3. Saurabh Dixit, MurtadaTaha, Shree R. Singh, and Vida A. Dennis. 2014.  Activation of antigen presenting cells and induction of mucosal antibodies by Chlamydia trachomatis outer membrane peptide encapsulated within PLA-PEG nanoparticles. TechConnect World Conference (NSTI), June 16-18, 2014, in National Harbor, MD.

4. Abebayehu N. Yilma, Shree R. Singh, Saurabh Dixit, Gebremeskel G. Hidat, and Vida A. Dennis. Poly-Vinyl Pyrrolidone (PVP)-coated Silver (Ag) Nanoparticles (Ag-PVP): a Potential to Regulate Chlamydia trachomatis Inflammation. TechConnect World Conference (NSTI) 2013, May 12-16, 2013, National Harbor, MD.

5. Saurabh Dixit, Shree R. Singh, Abebayehu N. Yilma, Ronald Agee and Vida A. Dennis. 2013. PLA-PEG as a delivery system for a Chlamydia trachomatis subunit vaccine. TechConnect World Conference (NSTI) 2013, May 12-16, 2013, National Harbor, MD 

6. Erdal Eroglu, Alain B. Waffo, Vida A. Dennis and Shree R. Singh. 2012. Development of PHEMA-Chitosan nanospheres and encapsulation of RSV-F DNA vaccine. TechConnect World Conference (NSTI) 2012, June 18-21, 2012, Santa Clara, CA.

7. Abebayehu N. Yilma, Shree R. Singh, Stacie J. Fairley and Vida A. Dennis. 2012.  Smaller Sizes of Ag-PVP Nanoparticles Control Inflammatory Responses, and Reduce CD80 and CD86 Expression Levels in Macrophages Infected with Chlamydia trachomatis. TechConnect World Conference (NSTI) 2012, June 18-21, 2012, Santa Clara, CA.

8. Murtada Taha, Shree R. Singh, Courtney Moore, Ronald Agee and Vida A. Dennis. 2012. Encapsulation and Characterization of BSA in PLA-PEG Nanoparticles as a Model for Chlamydia trachomatis rMOMP-278 Protein Nanovaccine Delivery System. TechConnect World Conference (NSTI), 2012, June 18-21, 2012, Santa Clara, CA.

9. Praseetha Subbarayan, Vida A. Dennis, Carnella Lee, Elijah Nyairo and Shree R. Singh. 2011. Encapsulation and in vitro characterization of protein in PLGA-chitosan nanoparticles for efficient drug delivery. TechConnect World Conference (NSTI), June 13-16, Boston, MA.

10. Murtada Taha, Shree R. Singh, Chelsea Butler, Elijah Nyairo, Vida A. Dennis. 2011. Characterization of rMOMP-187 Peptide Encapsulated in PLGA 50:50 Nanoparticles. TechConnect World Conference (NSTI), June 13-16, Boston, MA.

11. Yilma, A. N., Singh, S. R., Taha, M. A., Fairley, S. J., and Dennis, V. A. 2011. Evidence of the anti-inflammatory effect of silver-polyvinyl pyrrolidone nanoparticles (Ag-PVP) in Chlamydia trachomatis infected macrophage and HeLa cells. TechConnect World Conference (NSTI), June 13-16, Boston, MA (Oral).

 

Patents

Shree R. Singh, Pooja Tiwari, Vida A. Dennis 
ANTI RESPIRATORY SYNCYTIAL VIRUS PEPTIDE FUNCTIONALIZED GOLD NANOPARTICLES Application Serial No: 13/722,517

Synergistic Activities (Last 5 years)

• Member of the Editorial Advisory Board of Science @ ASU (ASU)
• Manager of Immunology Core at ASU
• Reviewer: PLoS ONE, Frontiers of Microbial Immunology, Nanomedicine, Vaccine, Biomaterials
• Editor, PLOS ONE
• Editor, Frontiers of Microbial Immunology
• Editor, Editor, Journal of Nanogenomics and Nanomedicine (NGNM)
• NIH Scientific Review Panels (Immunology Fellowship;  AREA grants; SBIR and R21)

Collaborations

• University of Louisiana at Lafayette (Dr. Villinger)
• Tulane University (Drs. Philipp, Kaushal, Embers)
• Central Drug Research Institute, India (Dr. Murthy)
• IDEHU, CONICET/UBA , Argentina (Dr. Giambartolomei)
• WRAI (Dr. Gautam)
• Louisiana State University (Dr. Bakeer)
• Bluefield State College (Dr. Belay)
• Addis Ababa University (Dr. Yimtu)
• Jimma University (Dr. Haileamlak)
• Mekelle University (Dr. Zerihun)

Students/Postgraduates trained (Last 5 years)

Ph.D: 11 students
Postdoctoral fellows: 4
MS: 2
Undergraduates: 12

 

PRESENTATIONS (last 5 years)

Over 150 presentations at regional, national and international conferences