Using a combination of new technologies, drugs can be coated with nanofibers and delivered to the affected body parts in a controlled manner. Thus, a very small quantity of drug could prove to be beneficial without harmful side effects of large doses. The aim of this project is to create controlled drug release systems based on encapsulated nanofibers. The Emulsion Electrospun Fibers (EEFs) are constructed and used as drug delivery vehicle. Nanometer size particles of PLGA are prepared which are spherical in shape. PVA is added and by electrospinning encapsulated nanofibers are prepared. Properties such as size, morphology, concentration of PLGA, drug delivery efficiency of nanofibers, encapsulation efficiency, cytotoxicty and other essential parameters are analyzed and tested in vitro using human cell lines to assess the effectiveness for its further validation in an animal model.