Chlamydia trachomatis is a human pathogen that is not only a sexually transmitted disease but also causes severe eye infection leading to blindness. Control of Chlamydia and other pathogens in the environment will greatly improve our health and the environment.  Anti-Chlamydial peptides can inhibit infection and induce a strong immune response. One of the obstacles in administration of peptides to induce immune response is the lack of peptides to target antigen presenting cells. Therefore, peptides in combination with nanoparticles are an excellent choice as a delivery agent due to their ability to target antigen presenting cells. We use poly (lactic-eo-glycolic acid) (PLGA) and monophospholipid A (MPLA) nanoparticles to encapsulate anti-Chlamydial peptides and administer them in mice. The immune responses are studied.