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Dr. Shree Ram Singh
Associate Professor of Biology  
 
 
Dr. Shree R. Singh is an associate professor of biology in the department. He received his MS degrees from ND University in India and Alabama State University. Dr. Singh received his Ph.D. degree in Microbiology from Auburn University. He teaches general biology courses offered within the department.
 
Dr. Singh is involved in various other activities besides teaching. He serves as the Program Director of HBCU-UP program on campus that is designed to strengthen Science, Technology, Engineering and Mathematics (STEM) program at ASU.  Visit the website http://www.alasu.edu/hbcuup to get more information about the program.  
 
Dr. Singh’s research focus is respiratory syncytial virus (RSV) that causes common cold like symptoms to severe bronchiolitis and pneumonia in children and older population. Dr. Singh’s research is a triangular approach dealing with prevention, diagnosis, and therpeutics. Dr. Singh’s multidisciplinary approach to deal with the RSV disease involves many molecular biology, virology, immunology, proteomics, nanotechnology and engineering techniques. Many of the projects are undertaken by post-doctoral associates, research assistants, graduate and undergraduate students. Some of research topics are listed below:  
 
  1. Development of recombinant protein vaccine against RSV.
  2. Design and evaluation of DNA vaccine
  3. Adeno-associated vectors based vaccine
  4. Adenoviral vaccines against RSV
  5. Silencing of RSV genes using siRNA technology
  6. Inhibition of RSV using nanoparticles
  7. Design and development of immunosensors to detect RSV
  8. Development of DNA based diagnostic tools for RSV
Most of these projects are funded through National Institutes of Health and National Science Foundation. Many of these projects are conducted in collaboration with other research institutions including-Tulane National Primate Center, University of South Florida, Auburn University, University of Louisville and University of Florida. Dr. Singh’s research program focus is to train minority students in the lab. In this effort, several undergraduate and graduate students have been trained in recent past.  For more information on Dr. Singh's research, go to http://www.alasu.edu/hbcuup and http://www.alasu.edu/crest.
 
Some of the most recent research publications:  
 
  1. Singh S. R., K. Hulett, S. R. Pillai, V. Dennis, K.M. Oh, K. Scissum-Gunn . 2006. Mucosal immunization with recombinant MOMP genetically linked with modified cholera toxin confers protection against Chlamydia trachomatis infection. Vaccine Vol. 24:1213-24.
     
  2. Dennis, V.A., A. Jefferson, S.R. Singh, F. Ganapamo, M.T. Phillip. 2006. Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease: a possible role for suppression of cytokine signalling 1 and 3. Infect. Immun. 74 (10):5780-89.
     
  3. Zekri, S., A., Kumar, S.R. Singh, A. Kumar. 2006. Analysis of nanocavity DNA biochip for respiratory syncytial virus (RSV) diagnosis. J. Biomed. Nanotech. (Under Review)
     
  4. Singh, S. R., V. A. Dennis, C. L. Carter, S. R. Pillai, A. Jefferson, S. V. Sahi, E. G. Moore. 2006.
     
  5. Recombinant RSV-F protein genetically linked with modified cholera toxin induces Th1/Th2 mixed immune response. (In preparation)
     
  6. Singh, S. R., V. A. Dennis, C. L. Carter, S. R. Pillai, S. V. Sahi, E. G. Moore. 2006. Respiratory Syncytial Virus Recombinant F protein (residues 255-278) induces Th1 immune response. (In preparation
  7. Lee, K. G., S. R. Pillai, S. R. Singh, G. A. Willing. 2006. The investigation of Protein A and Salmonella antibody adsorption onto biosensor surfaces by atomic force microscopy. (In preparation)
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